Climate change is making us sick, and urgent action is a matter of life and death. Prioritizing health and well-being in climate action is not only a moral and legal imperative but a strategic opportunity to unlock transformative health benefits, secure economic opportunity, and ensure a just and equitable future. The COP29 Special Report on Climate Change and Health outlines priority actions from the global health community for governments, policymakers, and other sectors to place health at the heart of climate solutions. Developed by the World Health Organization with over 100 organizations and 300 experts, the report emphasizes health as the definitive argument for climate action across people, place, and planet, through seven key messages and critical asks. This report is a call to action: the success of collective efforts to combat climate change will be measured not only by greenhouse gas reductions but also in tangible improvements in people’s lives. It highlights opportunities to reduce health inequalities, bridge the development gap, and presents a vision for a just, resilient, sustainable, and healthy future.